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System and method for optical imaging with vertical cavity surface emitting lasers Abstract The present invention uses vertical-cavity surface-emitting lasers (VCSELs) as illumination source for simultaneous imaging of blood flow and tissue oxygenation dynamics in vivo, or a means to monitor neural activity in brain slices ex vivo. The speckle pattern on the brain tissue due to a VCSEL's coherence properties is the main challenge to producing low-noise high-brightness illumination, required for evaluating tissue oxygenation. Moreover, using oxide-confined VCSELs we show a fast switching from a single-mode operation scheme to a special multi-modal, multi-wavelength rapid sweep scheme. The multi-modal, multi-wavelength rapid sweep scheme reduces noise values to within a factor of 40% compared to non-coherent LED illumination, enabling high-brightness VCSELs to act as efficient miniature light sources for various brain imaging modalities and other imaging applications. These VCSELs are promising for long-term portable continuous monitoring of brain dynamics in freely moving animals. Inventors: Munro; Elizabeth Alice (Toronto, CA), Levi; Ofer (Los Altos, CA) Applicant: Name City State Country Type Munro; Elizabeth Alice Levi; Ofer Toronto Los Altos N/A CA CA US Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Toronto, Ontario, CA) Family ID: 060 Appl. No.: 13/357,070 Filed: January 24, 2012.